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Mol. Cells 2011; 32(6): 491-509
Published online December 31, 2011
https://doi.org/10.1007/s10059-011-0276-3
© The Korean Society for Molecular and Cellular Biology
Regulation of Reactive Oxygen Species Generation in Cell Signaling
Correspondence to : *Correspondence: baeys@ewha.ac.kr (YSB); rheesg@ewha.ac.kr (SGR); ydy1130@korea.ac.kr (YDY)
Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be by-products of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.
Keywords apoptosis, cell signaling, cytochrome p450, mitochondria, NADPH oxidase, reactive oxygen species
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Mol. Cells 2011; 32(6): 491-509
Published online December 31, 2011 https://doi.org/10.1007/s10059-011-0276-3
Copyright © The Korean Society for Molecular and Cellular Biology.
Regulation of Reactive Oxygen Species Generation in Cell Signaling
Yun Soo Bae1,*, Hyunjin Oh1, Sue Goo Rhee1,*, and Young Do Yoo2,*
1Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea, 2Laboratory of Molecular Cell Biology, Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705, Korea
Correspondence to:*Correspondence: baeys@ewha.ac.kr (YSB); rheesg@ewha.ac.kr (SGR); ydy1130@korea.ac.kr (YDY)
Abstract
Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be by-products of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.
Keywords: apoptosis, cell signaling, cytochrome p450, mitochondria, NADPH oxidase, reactive oxygen species
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